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观察了NPC患者和不同滴度IgA/VCA者的T淋巴细胞亚群、免疫球蛋白(IgG、IgA、IgM)和补体C3的变化。结果提示,鼻咽癌患者的T细胞亚群失调,细胞免疫功能明显降低而体液免疫功能明显增高;NPC患病风险者──高滴度IgA/VCA者的免疫功能发生了与NPC患者相似的变化;低滴度IgA/VCA者的细胞免疫功能也开始趋向于抑制状态。研究结果为NPC发病的免疫机制和防治提供了重要的实验依据。
The changes of T lymphocyte subsets, immunoglobulins (IgG, IgA, IgM) and complement C3 in patients with NPC and those with different titer of IgA / VCA were observed. The results suggest that the T cell subsets of NPC patients are imbalanced, the cellular immune function is significantly reduced and the humoral immunity function is obviously increased. The immunological function of those with high titer of IgA / VCA at NPC risk is similar to that of NPC Changes; low-titer IgA / VCA cellular immune function also began to tend to inhibit the state. The results provide important experimental evidence for the pathogenesis and prevention of NPC.