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目的探讨缺血修饰白蛋白(IMA)和肌红蛋白在急性冠脉综合征(ACS)诊断中的应用。方法对疑似急性冠脉综合征患者,在胸痛发作4小时内采血检测缺血修饰白蛋白、肌红蛋白(Mb)和肌钙蛋白I(CTnI),观察缺血修饰白蛋白和肌红蛋白对急性冠脉综合征的诊断价值。结果缺血修饰白蛋白和肌红蛋白对急性冠脉综合征诊断的敏感性分别为83%,69%,特异性分别为46%,43%。IMA、Mb、CTnI联合检测敏感性提高到96%。结论缺血修饰白蛋白是诊断急性冠脉综合征的敏感指标,三者联合检测可明显提高ACS早期诊断敏感性。
Objective To investigate the application of IMA and myoglobin in the diagnosis of acute coronary syndrome (ACS). Methods In patients with suspected acute coronary syndromes, ischemia-modified albumin, myoglobin (Mb) and troponin I (CTnI) were detected within 4 hours after onset of chest pain. The effects of ischemia-modified albumin and myoglobin Diagnostic value of acute coronary syndrome. Results The sensitivity of ischemic modified albumin and myoglobin to the diagnosis of acute coronary syndrome were 83% and 69% respectively, and the specificity was 46% and 43% respectively. IMA, Mb, CTnI joint detection sensitivity increased to 96%. Conclusions Ischemia-modified albumin is a sensitive indicator for the diagnosis of acute coronary syndromes. Combined detection of the three can significantly improve the sensitivity of early diagnosis of ACS.