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皮肤及皮下组织坏死是双香豆素及同类药的一种罕见并发症,它发生突然,能危及生命.作者报道两例这种并发症,并复习有关文献,对其临床特点、病因、病理生理和治疗进行讨论.例1,女,19岁,有两次深静脉血栓形成既往史.第二次发病时,因左腿疼痛肿胀数日入院,体检时见左腿水肿,腓肠肌触痛,实验室检查正常,静脉造影显示左腿深静脉血栓形成,连续静脉肝素滴注4天后,给予华法令.开始两天15mg,以后每天5mg,华法令治疗第三天停用肝素.
Skin and subcutaneous tissue necrosis is a rare complication of dicoumarol and its like drugs, which occurs suddenly, can be life-threatening. The authors reported two cases of this complication and reviewed the literature on its clinical features, etiology, pathology Physiotherapy and treatment were discussed.Example 1, female, 19 years old, there are two previous history of deep vein thrombosis.Second episode, due to swelling of the left leg for several days hospitalization, physical examination, see left leg edema, gastrocnemius tenderness, Laboratory tests were normal and venous angiography showed deep vein thrombosis of the left leg. Warfarin was given 4 days after continuous intravenous heparin infusion, starting 15 mg for two days and 5 mg daily thereafter. Heparin was discontinued on the third day after warfarin treatment.