【摘 要】
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The immune regulatory and antioxidant roles of Ganoderma lucidum were investigated using cyclophosphamide (CTX)-induced immunosuppressed mice. Mice were randoml
【机 构】
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College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
论文部分内容阅读
The immune regulatory and antioxidant roles of Ganoderma lucidum were investigated using cyclophosphamide (CTX)-induced immunosuppressed mice. Mice were randomly divided into groups: untreated (groupⅠ), immunosuppressed (groupⅡ), unfermented G. lucidum polysaccharide (groupⅢ) and fermented G. lucidum polysaccharide (groupⅣ). After seven consecutive days of treatments, the serum concentration of IL-4, IFN-gamma, IgG, IgA and IgM and the liver activity of GSH-Px, SOD, CAT and MDA enzymes were analyzed. The contents of IL-4, IFN-γ in serum and GSH-Px, SOD and CAT in liver tissues were significantly reduced in groupⅡ compared with those in group I, indicating successful CTX-induced immunosuppression. Interestingly, the results showed that the above immune and antioxidant indicators were significantly improved after G. lucidum polysaccharide treatment, regardless of fermentation. However, fermentation caused changes in polysaccharide structure, which might have a significant impact on immune regulation and antioxidant functions in immunosuppressed mice.
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