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伯氏疟原虫氯喹敏感株(CS)和抗氯喹株(CR)感染红细胞中的游离氨基酸量和鸟氨酸脱羧酶活力均相接近,用氯喹10mg/kg im两个株的感染小鼠,20h后对游离氨基酸无抑制作用.氯喹剂量为5mg/kg时,抑制CS和CR感染红细胞的鸟氨酸脱羧酶活力为79.6和55.7％。 CS和CR感染红细胞中的精脒量为139±27和528±140nmol/10~9感染红细胞。环亮氨酸剂量为80mg/kg时,能抑制CS和CR感染红细胞的精脒生成,其抑制率分别为44和57％,加喂甲硫氨酸(100mg/kg)后,精脒量分别上升至294和657nmol/10~9感染红细胞。但是与两者仍有一定差距,故认为在S-腺苷甲硫氨酸合成酶及其后的代谢环节仍有差异.
The amount of free amino acids and ornithine decarboxylase activity in erythrocytes infected by chloroquine sensitive strains (CS) and chloroquine resistant strains (CR) of P. berghei were close to each other. The infected mice with two strains of chloroquine 10 mg / kg im for 20 h No inhibitory effect on free amino acids.Unclosing at the dosage of 5 mg / kg, ornithine decarboxylase activity of erythrocytes infected by CS and CR was 79.6 and 55.7%, respectively. The amount of spermine in CS and CR-infected erythrocytes was 139 ± 27 and 528 ± 140 nmol / 10-9 infected erythrocytes. Cyclofucine dose of 80mg / kg, can inhibit CS and CR-infected erythrocyte spermidine production, the inhibition rates were 44 and 57%, respectively, after adding methionine (100mg / kg), spermine amount Rose to 294 and 657nmol / 10 ~ 9 infected red blood cells. But there is still a certain gap between the two, so that the S-adenosylmethionine synthetase and its subsequent metabolic links are still different.