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Caspases家族是一类促凋亡蛋白,代表着一类细胞内的蛋白酶系统,在凋亡各个阶段发挥重要作用。细胞凋亡的发生是一个复杂caspase家族引导的蛋白酶级联反应过程,不同的细胞或不同信号转导途径诱发的凋亡过程中参与的caspase有所不同,其中caspase-3是凋亡的执行者,caspase-9在线粒体凋亡过程中发挥重要作用。现就其结构、机制,在妇科疾病中的表达及基因治疗等方面进行阐述,为妇科疾病的诊断治疗开辟新的途径。
The Caspases family is a class of pro-apoptotic proteins that represent a class of intracellular protease systems that play an important role in all stages of apoptosis. Apoptosis is a complex Caspase family-guided cascade of protease cascade, different cells or different signal transduction pathway-induced apoptosis in the caspase involved in different, including caspase-3 is the perpetrator of apoptosis , caspase-9 plays an important role in mitochondrial apoptosis. Now its structure, mechanism, expression in gynecological diseases and gene therapy and other aspects of exposition for the diagnosis and treatment of gynecological diseases to open up new avenues.