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目的:分析腹腔热灌注化疗结合免疫治疗机治疗恶性腹水的临床效果。方法:选取我院于2010年12月~2012年12月收治的100例恶性腹水患者作为观察对象,随机将其分为对照组和观察组2组,对照组患者进行腹腔热灌注化疗,观察组患者在此基础上进行免疫治疗机治疗,观察并比较2组患者的治疗效果。结果:观察组患者的有效率为90%,对照组患者的有效率为70%,2组患者有效率比较差异有统计学意义(P<0.05)。治疗过程中观察组患者有9例患者发生恶心呕吐,7例发生腹痛腹胀,2例患者发生骨髓抑制,对照组有15例患者发生恶心呕吐,10例患者发生腹痛腹胀,6例患者发生骨髓抑制,2组患者不良反应发生情况比较差异有统计学意义(P<0.05)。结论:腹腔热灌注化疗结合免疫治疗机治疗恶性腹水有着良好的临床效果,且不良反应少,可以在临床上广泛推广。
Objective: To analyze the clinical effect of intraperitoneal hyperthermic chemotherapy combined with immunotherapy in the treatment of malignant ascites. Methods: A total of 100 cases of malignant ascites treated in our hospital from December 2010 to December 2012 were selected as observation subjects and randomly divided into two groups: control group and observation group. Patients in control group were treated with intraperitoneal hyperthermic perfusion chemotherapy and observation group On this basis, patients were treated with immunotherapy machine, the treatment effect was observed and compared between the two groups. Results: The effective rate of the observation group was 90%, while that of the control group was 70%. The effective rate of the two groups was statistically significant (P <0.05). Nausea and vomiting occurred in 9 patients in the observation group during the course of treatment, abdominal distension occurred in 7 patients, bone marrow suppression was observed in 2 patients, nausea and vomiting occurred in 15 patients in the control group, abdominal pain and abdominal distension occurred in 10 patients and bone marrow suppression occurred in 6 patients There was significant difference in adverse reactions between the two groups (P <0.05). Conclusion: Intraperitoneal hyperthermic perfusion chemotherapy combined with immunotherapy machine has a good clinical effect in treatment of malignant ascites, and has few side effects. It can be widely used clinically.