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目的探讨不同类型冠心病患者血清抗丙二醛-乙醛加合物抗体IgG水平变化及其临床意义。方法87例入选患者根据临床及冠状动脉造影结果分为对照组30例,稳定型心绞痛组15例,不稳定型心绞痛组12例,急性心肌梗死组30例。应用ELISA测定血清抗丙二醛-乙醛加合物抗体IgG水平。结果稳定型心绞痛组、不稳定型心绞痛组和急性心肌梗死组血清抗丙二醛-乙醛加合物抗体IgG水平显著高于对照组(P<0.05),急性心肌梗死组和不稳定型心绞痛组血清抗丙二醛-乙醛加合物抗体IgG水平显著高于稳定型心绞痛组(P<0.05),而不稳定型心绞痛组和急性心肌梗死组无显著性差异(P>0.05)。结论血清抗丙二醛-乙醛加合物抗体IgG水平和冠心病的发生发展明显相关,对冠心病尤其是急性冠状动脉综合征有很好的预测作用。
Objective To investigate the changes of serum anti-malondialdehyde-acetaldehyde adduct IgG in patients with different types of coronary heart disease and its clinical significance. Methods According to the results of clinical and coronary angiography, 87 patients were divided into control group (30 cases), stable angina group (15 cases), unstable angina group (12 cases) and acute myocardial infarction group (30 cases). Serum anti-malondialdehyde-acetaldehyde adduct IgG levels were measured by ELISA. Results The levels of serum anti-malondialdehyde-acetaldehyde adduct IgG in patients with stable angina, unstable angina and acute myocardial infarction were significantly higher than those in the control group (P <0.05). The levels of IgG in patients with acute myocardial infarction and unstable angina Serum anti-malondialdehyde-acetaldehyde adduct antibody IgG levels were significantly higher in patients with stable angina pectoris (P <0.05), but there was no significant difference between unstable angina pectoris group and acute myocardial infarction group (P> 0.05). Conclusions Serum anti-malondialdehyde-acetaldehyde adduct IgG level is significantly correlated with the occurrence and development of coronary heart disease, and has a good predictive value for coronary heart disease, especially acute coronary syndrome.