论文部分内容阅读
我们应用免疫组织化学方法检测了100例肺癌患者手术切除的组织标本,探讨了增殖细胞核抗原(PCNA)在不同组织学类型及不同分化程度的肺癌组织中的分布及其相关性。实验结果发现,所有肺癌组织都可见到 PCNA 染色阳性的细胞,但 PCNA 阳性细胞的数量在不同类型的癌组织及不同分化程度的癌组织中有明显差异。其中以未分化癌的 PCNA 阳性率最高,腺癌次之,鳞癌最低。低分化癌最高,中分化癌次之,高分化癌最低。小细胞未分化癌高于非小细胞未分化癌。本实验结果表明,PCNA 的表达与肺癌的组织学类型及分化程度呈明显相关性,从而提示 PCNA 的表达可作为细胞增殖活性和肿瘤组织恶性程度评价的一个重要参考指标。
We used immunohistochemical methods to detect tissue specimens from 100 patients with lung cancer and to investigate the distribution and correlation of proliferating cell nuclear antigen (PCNA) in different histological types and different degrees of differentiation of lung cancer. The experimental results showed that PCNA-positive cells could be seen in all lung cancer tissues, but the number of PCNA-positive cells was significantly different in different types of cancer tissues and cancer tissues with different degrees of differentiation. Among them, the highest positive rate of PCNA was undifferentiated carcinoma, followed by adenocarcinoma, and the lowest was squamous cell carcinoma. Poorly differentiated cancers were the most advanced, followed by moderately differentiated cancers, and well-differentiated cancers were the lowest. Small cell undifferentiated carcinoma is higher than non-small cell undifferentiated carcinoma. The results of this experiment indicate that the expression of PCNA is significantly correlated with the histological type and differentiation of lung cancer, suggesting that the expression of PCNA may serve as an important reference index for evaluation of cell proliferation activity and malignancy of tumor tissue.