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Beneat 和 Galeazzi 已用一种统计矩分析的非房室方法来评价静注单剂量后的稳态分布容积 V_(SS)。此法适用于药物全部从中室消除的一级动力学体系。对于多剂量给药,V_(SS)的估计值会过高。本文运用统计矩原理,提供精确的数学公式,计算稳态下多剂量的表现分布容积V_(SS)多剂量静注给药后,利用恒等式
Beneat and Galeazzi have used a non-compartmental method of statistical moment analysis to assess the steady state volume of distribution V_ (SS) after a single intravenous dose. This method applies to all drugs from the chamber to eliminate a dynamic system. For multiple doses, the estimate of V_ (SS) will be too high. In this paper, we use the principle of statistical moments to provide accurate mathematical formulas to calculate steady-state multi-dose distribution of volume V_ (SS) after multiple doses of intravenous administration, the use of identity