目的　探讨在运动状态下索他洛尔对心室复极作用的性别差异。方法　研究以随机、双盲、安慰剂、自身对照为原则 ,对 31例男性和 30例女性健康志愿者 ,通过活动平板运动试验 ,分别观察口服索他洛尔后静息时和运动时男女之间体表心电图上反映心室复极过程的QTc和JTc间期的不同变化 ,并用安慰剂做对照。结果　口服索他洛尔后 ,静息时女性的JTc间期显著长于男性 ,分别为 :(2 71 0 5± 18 0 9)ms比 (2 2 9 75± 15 5 9)ms ,P <0 0 0 1;男、女运动高峰时JTc缩短的百分率 :服索他洛尔时为 3 6 4 %±4 93%比 13 2 6 %± 6 0 9% ,P <0 0 1;此时男、女JTc间期的差异消失 ,分别为 :(2 2 0 17± 13 0 4 )ms比(2 19 4 8± 10 85 )ms,P >0 0 5。结论　口服索他洛尔后 ,虽然静息时女性的心室复极时间明显长于男性 ,但运动中女性心室复极时间的缩短比男性显著 ,这种性别之间的差异比口服安慰剂时更明显 Objective To investigate the gender differences of sotalol in ventricular repolarization during exercise. Methods Randomized, double-blind, placebo and self-control principle, 31 male and 30 healthy female volunteers, through the activity of treadmill exercise test were observed after oral sotalol resting and during exercise between men and women The changes of QTc and JTc between ventricular repolarization on the body surface electrocardiogram were observed and compared with placebo. Results After oral sotalol, the resting JTc interval was significantly longer in women than in men (2 71 5 ± 18 0 9 ms vs (2 2 9 75 ± 15 5 9) ms P <0 0 0 1; The percentage of JTc shortening at the peak of male and female sports: 36.4% ± 4 93% vs 132.6% ± 60.9%, P <0.01 when taking sotalol; The differences in female JTc interval disappeared: (2 2 0 17 ± 13 0 4) ms (2 19 4 8 ± 10 85) ms, P 0 05, respectively. Conclusions After sotalol was administered orally, although the ventricular repolarization time was significantly longer in women than in men at rest, the ventricular repolarization time was significantly shorter in women than in men during exercise, and the difference between these sexes was more pronounced than that of oral placebo