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目的:研究调气消积汤的急性毒性,确定其安全范围,为临床安全用药提供实验依据。方法:应用不同浓度的调气消积汤给小鼠灌胃,观察小鼠的毒性反应,记录死亡情况,测定小鼠的最大给药量。结果:实验小鼠未出现毒性反应,与对照组比较,体重变化差异不显著(P>0.05),最大给药量为198g/(kg·d),相当于60kg体重成人临床推荐剂量的108倍。结论:调气消积汤的临床剂量服用安全。
Objective: To study the acute toxicity of Tiaoqixiaoji Decoction, determine its safety scope, and provide experimental basis for clinical safe drug use. Methods: The mice were intragastrically administered with different concentrations of Tiaoqi Xiaoji Decoction. The toxicity of the mice was observed. The death was recorded and the maximum dose of the mice was determined. RESULTS: There was no toxic reaction in the experimental mice. There was no significant difference in body weight change compared with the control group (P>0.05). The maximum dose was 198 g/(kg·d), which was equivalent to 108 times the clinical recommended dose for 60 kg weight adults. . Conclusion: The clinical dosage of Tiaoqixiaoji Decoction is safe.