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作者用艮他霉素和托普霉素治疗258例拟诊为败血症的患者。在临床试验中,采用了前瞻性的、随机化的双盲研究方法;严格掌握这些氨基糖苷抗生素的剂量,使抗生素经20～30分钟输入后1小时的血浆浓度维持在5～10μg/ml范围内。对其中分别使用该两种抗生素9次以上,并且无其他造成急性肾功能衰竭原因的146例,测定了一系列血清肌酐值,进行该两种抗生素肾脏毒性的比较研究。如果血清肌酐初值小于3.0mg％,治疗中或治疗后48小时内增加了0.5mg％,或者血清肌酐初值大于等于3.0mg％,增加了1mg％,都判为发生肾脏
The authors treated 258 patients with suspected sepsis with gentamicin and tobramycin. In clinical trials, a prospective, randomized, double-blind study was used; the doses of these aminoglycoside antibiotics were rigorously controlled to maintain the plasma concentration of antibiotics at 5 to 10 μg / ml for 1 hour after 20 to 30 minutes of infusion Inside. A total of 146 patients who had used the two antibiotics for more than 9 times without any cause of acute renal failure were tested for a series of serum creatinine values and compared the renal toxicity of the two antibiotics. If the serum creatinine initial value is less than 3.0mg%, during or after treatment within 48 hours increased by 0.5mg%, or serum creatinine initial value is equal to or greater than 3.0mg%, an increase of 1mg%, were convicted of kidney