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分析了对小鼠两次腹腔注射染毒高、低剂量氯化镉（１．５ｍｇ／ｋｇ或３ｍｇ／ｋｇ，醋酸铅（６０ｍｇ／ｋｇ或１２０ｍｇ／ｋｇ）和重铬酸钾（７．５ｍｇ／ｋｇ或１５ｍｇ／ｋｇ）后，骨髓细胞中Ａｇ一ＮＯＲｓ的变化情况。与对照组比较，各实验组有２Ａｇ一ＮＯＲｓ染色体的细胞的百分比和平均每个细胞有２Ａｇ一ＮＯＲｓ染色体数均显著减少（Ｐ＜０．０５）。提示细胞中的ｒＲＮＡ基因活性受到抑制，这可能与铬、镉和铅３种化合物能影响机体和细胞代谢，损伤遗传物质，基因的遗传背景有关。各实验组中的高、低剂量组间的上述两项指标差异均不显著（Ｐ＞０．０５）
The effects of high and low doses of cadmium chloride (1.5 mg / kg or 3 mg / kg, lead acetate (60 mg / kg or 120 mg / kg) and potassium dichromate (7.5 mg / kg Or 15 mg / kg), the percentage of cells with 2Ag-NORs and the number of 2Ag-NORs per cell in each experimental group were significantly decreased (P <0.05), suggesting that the activity of rRNA gene in cells was inhibited, which may be related to the three compounds of chromium, cadmium and lead can affect the body and cell metabolism, genetic damage of genetic material, genetic background related to the high , There was no significant difference between the two indexes in the low-dose group (P> 0.05)