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目的探讨糖尿病周围神经病变(DPN)应用前列地尔联合依帕司他治疗的效果。方法 84例DPN患者,随机分为A组与B组,每组42例。A组予以前列地尔联合依帕司他治疗,B组予以常规治疗,对比两组的疗效。结果 A组治疗总有效率为92.86%,显著高于B组的73.81%,差异具有统计学意义(P<0.05);治疗后A组的运动神经和感觉神经的传导速度均显著高于B组,差异具有统计学意义(P<0.05)。结论前列地尔联合依帕司他治疗DPN能够改善患者的神经传导功能,提高临床疗效,值得推广应用。
Objective To investigate the effect of application of prostaglandin combined with epalrestat on diabetic peripheral neuropathy (DPN). Methods 84 cases of DPN patients were randomly divided into group A and group B, 42 cases in each group. Group A was treated with alprostadil in combination with alprostadil, while group B was given conventional treatment. The curative effect was compared between the two groups. Results The total effective rate of group A was 92.86%, which was significantly higher than that of group B (73.81%), the difference was statistically significant (P <0.05). After treatment, the motor nerve and sensory nerve conduction velocity in group A were significantly higher than those in group B , The difference was statistically significant (P <0.05). Conclusion The combination of alprostadil and alprostadil for the treatment of DPN can improve the neurotransmission function of patients and improve the clinical curative effect, which is worth popularizing and applying.