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Gilbert综合征和Crig1er-NajjarⅡ型病患者在热卡缺乏一天后,血浆非结合胆红素浓度明显增加。十余年来,这种禁食性高胆红素血症引起了很大兴趣。研究禁食性高胆红素血症可促进对胆红素代谢和转运的了解。多种动物和突变种如先天性缺乏胆红素UDP-葡萄糖醛酸转移酶的Gunn大鼠也能发生明显的禁食性高胆红素血症,可用作实验模型。新近,观察不同饮食成分对Gilbert综合征患者和Gunn大鼠血浆胆红素浓度作用的结果提示,禁食和饮食性高胆红素血症的发生机理可能不同,在不同种动物中也可能不同。本文旨在描述禁食性高胆红素血症的临床全貌、探讨所提
Gilbert’s syndrome and Crig1er-Najjar type II patients with a lack of heat card one day after the plasma unconjugated bilirubin concentration was significantly increased. For more than a decade, this fasting hyperbilirubinemia has drawn great interest. Studying fasting hyperbilirubinemia can promote understanding of bilirubin metabolism and transport. Gunn rats of a variety of animals and mutants such as congenital lack of bilirubin UDP-glucuronosyltransferase also developed significant fasting hyperbilirubinemia and could be used as experimental models. Recently, the observation of the effects of different dietary components on plasma bilirubin concentrations in patients with Gilbert’s syndrome and Gunn rats suggests that the mechanism of fasting and diet-induced hyperbilirubinemia may be different and may vary from species to species . This article aims to describe the clinical picture of fasting hyperbilirubinemia, to explore the proposed