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从七十年代末起,生物素和抗生物素系统(Avidin-Biotin System)开始在免疫化学领域中逐渐得到广泛应用。特别是由于生物素和抗生物素间亲和力大、特异性强、试剂有商品供应,可分别结合各种类型大小分子,故在相当大的范围内,为免疫标记技术提供了极为方便有用的工具,成为被大家所喜爱采用的方法。 一、生物素和抗生物素发现的历史:生物素(Biotin)首先于1936年由Kogl和
Since the late seventies, biotin and the biotin system (Avidin-Biotin System) began to be widely used in the field of immunochemistry. In particular, due to the large affinity, strong specificity and high availability of biotin and biotin, reagents are available in a variety of sizes and sizes, respectively, and therefore provide a very convenient and useful tool for immunolabeling in a considerable range , Has become the favorite method used by everyone. First, the history of biotin and anti-biotin discovery: Biotin first in 1936 by Kogl and