According to the technical characteristics of short fixed wheelbase of a high-speed carriage, a subgrade-track integrated space mechanical response analysis model is proposed for trains under the action of biaxial load after the comparison of the stress distribution characteristics of the ballast track subgrade bed structures for high-speed railway under the action of uniaxial load and biaxial load. The loading threshold value(high-cycle long-term dynamic strength) under the circumstance where the cumulative deformation of subgrade structure gradually develops and finally reaches the convergent state, and its relationship with the foundation coefficient K30 were deduced, based on the characteristics of cumulative deformation evolution obtained from the unit structure filling model test under the action of cyclic loading. In view of structure stability and frost resistance requirements of the railway subgrade in cold regions, technical conditions to maintain good service performance of subgrade structure of high-speed railway ballasted track are discussed and analyzed. Study results show that the additive effect manifests itself obviously for railway train bogies under the action of biaxial load than uniaxial load, which has a significant dynamic effect on the subgrade bed bottom and a slight effect on the surface layer. Thus, the adoption of a biaxial load model in the design of a high-speed railway subgrade accurately reflects the vehicle load. Pursuant to the structure design principle, the design method of the subgrade structure of high-speed railway ballasted track is proposed to meet the technical requirements such as structural strength, bearing stiffness and high-cyclic and long-term stability. Technical indicators are obtained for the variation of thickness of the surface layer of reinforced subgrade bed in the double-layer subgrade mode along with the change of K30 at the subgrade bed bottom. The double-layer structure mode of “closure on the upper layer and drainage on the lower layer” was proposed in order to meet the waterproofing and drainage requirements of the upper layer of the subgrade bed in cold regions. A dense-framework graded gravel filler with weak water permeability at a coefficient of 10-4 cm/s is used on the upper layer and the void-framework graded gravel filler at the water permeability coefficient of 10-2 cm/s is adopted on the lower layer. According to the technical characteristics of short fixed wheelbase of a high-speed carriage, a subgrade-track integrated space mechanical response analysis model is proposed for trains under the action of biaxial load after the comparison of the stress distribution characteristics of the ballast track subgrade bed structures for high-speed railway under the action of uniaxial load and biaxial load. The loading threshold value (high-cycle long-term dynamic strength) under the circumstance where the cumulative deformation of subgrade structure gradually develops and finally reach the convergent state, and its relationship with the foundation coefficient K30 were deduced, based on the characteristics of cumulative deformation evolution obtained from the unit structure filling model test under the action of cyclic loading. In view of structure stability and frost resistance requirements of the railway subgrade in cold regions, technical conditions to maintain good service performance of subgrade structure of high-speed railway ballasted track are discussed and analyzed. Study results show that the additive effect manifests itself obviously for railway train bogies under the action of biaxial load than uniaxial load, which has a significant dynamic effect on the subgrade bed bottom and a slight effect on the surface layer. Thus, the adoption of a biaxial load model in the design of a high-speed railway subgrade precisely reflects the vehicle load. Pursuant to the structure design principle, the design method of the subgrade structure of high- speed railway ballasted track is proposed to meet the technical requirements such as structural strength, bearing stiffness and high-cyclic and long-term stability. technical indicators are obtained for the variation of thickness of the surface layer of reinforced subgrade bed in the double-layer subgrade mode along with the change of K30 at the subgrade bed bottom. The double-layer structure mode of “closure on the upper layer and drainage on the lower layer ”was proposed in order to meet the waterproofing and drainage requirements of the upper layer of the subgrade bed in cold regions. A dense-framework graded gravel filler with weak water permeability at a coefficient of 10-4 cm / s is used on the upper layer and the void-framework graded gravel filler at the water permeability coefficient of 10-2 cm / s is on the lower layer.