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目的评定以多西他赛为主联合化疗方案治疗晚期或复发的食道癌的疗效及毒副反应。方法对96例晚期或复发的食道癌患者以多西他赛为主联合化疗方案治疗随机分两组。治疗组:多西他赛、顺铂(DP方案)化疗;对照组:多西他赛、顺铂、氟脲嘧啶(DFP方案)化疗。结果治疗组:48例CR8例,PR23例,有效率65.58%;对照组:48例CR7例,PR23例,有效率62.5%。DP方案与DFP方案比较疗效相似,加氟脲嘧啶增加毒性而不增加疗效。结论DP方案是治疗晚期食道癌患者疗效高、毒副反应低的治疗方法之一。
Objective To evaluate the efficacy and side effects of docetaxel combined chemotherapy in the treatment of advanced or recurrent esophageal cancer. Methods A total of 96 patients with advanced or recurrent esophageal cancer were treated with docetaxel combined with chemotherapy. The patients were randomly divided into two groups. Treatment group: docetaxel, cisplatin (DP regimen) chemotherapy; control group: docetaxel, cisplatin, fluorouracil (DFP regimen) chemotherapy. Results The treatment group: 48 cases of CR8 cases, PR23 cases, the effective rate was 65.58%; control group: 48 cases of CR7 cases, PR23 cases, the effective rate was 62.5%. The efficacy of DP regimen was similar to that of DFP regimen, with fluorouracil increasing toxicity without increasing the efficacy. Conclusion DP regimen is one of the treatment methods for treating advanced esophageal cancer patients with high curative effect and low toxicity.