肾上腺髓质素 (adrenomedullin ,ADM)作为一种新发现的内分泌激素 ,广泛分布于机体的心、脑、肾、肺、肾上腺、血管内皮细胞等组织器官。在各种介导缺血再灌注损伤 (IR)的因素 ,如氧化应激、剪切应力改变、缺氧、细胞因子等诱导下ADM合成分泌增加 ,作为一种内源性保护介质 ,参与了心、肾、脑、骨等器官的IR发生发展 ,对防治IR具有重要作用 As a newly discovered endocrine hormone, adrenomedullin (ADM) is widely distributed in tissues and organs such as the heart, brain, kidney, lung, adrenal glands and vascular endothelial cells. In various mediators of ischemia-reperfusion injury (IR) such as oxidative stress, changes in shear stress, hypoxia, cytokines and other induced secretion of ADM synthesis increased, as an endogenous protective mediators involved in Heart, kidney, brain, bone and other organs of the IR development, prevention and treatment of IR has an important role