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鼻硬结病是一种慢性肉芽肿性传染病,多发生在鼻腔及上呼吸道。最初是维也纳皮科医生Hebra在1870年首先描述了该病,氏当时名之为硬鼻病。随后,1876年Mikulicz发表了他的组织学研究,报告了具有诊断意义的巨大泡沫状细胞,定名为Mikulicz氏细胞(以下简称M细胞)。1882年Frisch发现了本病的病原菌,即鼻硬结杆菌,定名为Frisch杆菌。至今一百年来,对本病发现和研究的文献陆续报道,全世界五大洲都有病例报告。
Nasal tuberculosis is a chronic granulomatous disease that occurs in the nasal and upper respiratory tract. He was first described by Hebra, a Vienna-based pico doctor, in 1870, then known as a rhinitis. Subsequently, Mikulicz published his histological study in 1876, reporting the diagnosis of giant foamy cells, designated as Mikulicz’s cells (hereinafter referred to as M cells). 1882 Frisch found the pathogen of the disease, that is, Corynebacterium nostrilis, named Frisch bacilli. So far a hundred years, the literature on the discovery and research of this disease have been reported one after another, there are case reports on the five continents of the world.