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目的:用拉曼和红外光谱法研究黄芩苷固体分散体的分散性,以期获得一种新的简单易行的检查固体分散体分散性的方法。方法:用溶剂法制备黄芩苷固体分散体,用显微共焦拉曼光谱仪、傅里叶变换红外光谱仪和X射线衍射仪分别采集黄芩苷、PVP K30,黄芩苷∶PVP K30(1∶6)的物理混合物及黄芩苷固体分散体的拉曼图谱、红外图谱和X射线衍射图谱并进行对比分析。结果:拉曼光谱法支持了采用X射线衍射法得到的药物在固体分散体中以无定形态存在的结果,从而确证了固体分散体中药物结晶态的消失。结论:拉曼光谱法快速、直接、对样品无损伤,是一种新的理想的检查固体分散体分散性的方法。
OBJECTIVE: To study the dispersibility of baicalin solid dispersion by Raman and infrared spectroscopy in order to obtain a new simple and easy method to check the dispersibility of solid dispersion. Methods: Baicalin solid dispersions were prepared by solvent method. Baicalin, PVP K30 and baicalin: PVP K30 (1: 6) were collected by micro-confocal Raman spectroscopy, Fourier transform infrared spectroscopy and X-ray diffractometry, respectively. The Raman spectra, IR spectra and X-ray diffraction patterns of Baicalin solid dispersions were compared and analyzed. Results: Raman spectroscopy supported the results of X-ray diffractometry of drug presence in the solid dispersion in amorphous form, confirming the disappearance of the crystalline state of the drug in the solid dispersion. Conclusion: Raman spectroscopy is a rapid, direct and non-destructive method for the samples. It is a new and ideal method to check the dispersibility of solid dispersions.