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目的探讨乙型病毒性肝炎与宫颈癌发病的相关性。方法对2005年1月~2007年10月来我院就诊的107例宫颈癌及116例非宫颈癌患者进行人乳头瘤病毒(HPV)16,18亚型和乙肝病毒血清五项标志物检测。以年龄校正的Logistic回归计算比值比(OR)和95%置信区间(CI)。结果宫颈癌组107例患者中HPV16,18阳性的60例(56.1%),而乙肝病毒血清五项标志物小三阳(HBsAg,抗-HBe,抗-HBc阳性)或大三阳(HBsAg,HBeAg,抗-HBc阳性)的10例(9.3%);非宫颈癌组116例中HPV16,18阳性的6例(5.2%),乙肝病毒血清标志物五项小三阳或大三阳的2例(1.7%)。结果显示,宫颈癌与HPV16,18以及乙型肝炎显著相关:对于HPV16,18,OR=23.3,95%CI 9.4~58.2,P=1.4×10-11,对于乙型肝炎,OR=6.3,95%CI 1.3~30.1,P=0.021。宫颈癌组的HPV16,18阳性率及乙型肝炎患病率均明显高于非宫颈癌组。结论乙型肝炎与女性宫颈癌存在相关性。
Objective To investigate the relationship between hepatitis B and cervical cancer. Methods A total of 107 cases of cervical cancer and 116 cases of non-cervical cancer treated in our hospital from January 2005 to October 2007 were tested for the five markers of human papilloma virus (HPV) 16,18 subtype and hepatitis B virus serum. Logistic regression was used to calculate odds ratio (OR) and 95% confidence interval (CI) using age-adjusted logistic regression. Results There were 60 positive cases (56.1%) of HPV16,18 in 107 cases of cervical cancer patients, while the positive rates of five positive markers of hepatitis B virus (HBsAg, anti-HBe, anti-HBc or HBsAg, HBeAg , Anti-HBc positive) in 10 cases (9.3%); non-cervical cancer group 116 cases of HPV16,18 positive in 6 cases (5.2%), hepatitis B virus serum markers five small three positive or three positive in 2 cases 1.7%). The results showed that cervical cancer was significantly associated with HPV16,18 and hepatitis B: OR = 23.3 for HPV16,18, 9.4-58.2 for P <0.05, P = 1.4x10-11, OR = 6.3,95 for hepatitis B % CI 1.3 ~ 30.1, P = 0.021. Cervical cancer group HPV16,18 positive rate and the prevalence of hepatitis B were significantly higher than non-cervical cancer group. Conclusion There is a correlation between hepatitis B and female cervical cancer.