【摘 要】
：
Cell type-specific genomic regulation is driven by the binding of transcription factors (TFs) in accessible genomic regions.Thus,chromatin accessibility can be used to identify cis-regulatory ele-ments and directly depict cellular identity.Single-cell Ass
【机 构】
：
NCMIS,CEMS,RCSDS,Academy of Mathematics and Systems Science,Chinese Academy of Sciences,Beijing 1001
论文部分内容阅读
Cell type-specific genomic regulation is driven by the binding of transcription factors (TFs) in accessible genomic regions.Thus,chromatin accessibility can be used to identify cis-regulatory ele-ments and directly depict cellular identity.Single-cell Assay for Transposase-Accessible Chromatin using sequencing (Single-cell ATAC-seq or scATAC-seq) has enabled genome-wide profiling of chromatin accessibility at single-cell resolution and can thus reveal epigenetic heterogeneity at cellular level [1].
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