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采用姐妹染色单体互换(SCE)、染色体畸变(CA)和细胞微核(MCN)三项检测指标观察21名服Ru—486妇女服药前后的细胞遗传学效应。经配对t检验处理后表明三项指标均无显著性差异(P>0.05)。作者认为: Ru—486短期一次性服用从细胞遗传学角度上看是安全的,不具有染色体损伤现象;经常服用是否对自身和下一代有细胞遗传学效应的影响,还需进一步研究。
The cytogenetic effects of 21 Ru-486 women before and after treatment were observed by using three detection indexes of sister chromatid exchange (SCE), chromosome aberration (CA) and micronuclei (MCN). Paired t-test showed that there was no significant difference between the three indicators (P> 0.05). The authors believe that: Ru-486 short-term one-time taking from the cytogenetic point of view is safe, does not have the phenomenon of chromosome damage; frequent taking whether it has on their own and the next generation of cytogenetic effects need further study.