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A multi-scale hardware and software architecture implementing the EMMS(energy-minimization multiscale) paradigm is proven to be effective in the simulation of a two-dimensional gas-solid suspension.General purpose CPUs are employed for macro-scale control and optimization,and many integrated cores(MICs) operating in multiple-instruction multiple-data mode are used for a molecular dynamics simulation of the solid particles at the meso-scale.Many cores operating in single-instruction multipledata mode,such as general purpose graphics processing units(GPGPUs),are employed for direct numerical simulation of the fluid flow at the micro-scale using the lattice Boltzmann method.This architecture is also expected to be efficient for the multi-scale simulation of other complex systems.