作者用天然的及以氢氧化铝吸附精制的破伤风类毒素及三联类毒素(破伤风桿菌,产气荚膜桿菌,水肿梭状芽胞桿菌)作为研究对象,研究利用电离辐射灭菌的可能性。用Co~(60)作为放射源,灭菌时照射剂量为150—200万仑琴,比较已经照射过及未照射过的制剂的免疫原性及抗原性。免疫原性的研究系将已经照射过的及未经照射过的破伤风类毒素二次肌肉内注射免疫小 The authors used tetanus toxoid and triplex toxins (Clostridium tetani, Clostridium perfringens, Clostridium volumicum) adsorbed and refined by natural aluminum hydroxide as the research object to study the possibility of using ionizing radiation to sterilize . Co ~ (60) as a radioactive source, irradiation dose of 150-200 million Lun Qin sterilization, has been irradiated and non-irradiated formulations compared immunogenicity and antigenicity. Immunogenicity studies have immunized mice with both irradiated and non-irradiated tetanus toxoid secondary intramuscular injections