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目的 探讨髓鞘碱蛋白 (MBP)对脑梗死 (CI)和多发性硬化 (MS)的诊断价值。方法 对 114例CI患者、2 8例 MS患者、2 4名正常者血清以及部分患者脑脊液 (CSF)的 MBP进行了检测。结果 CI、MS患者血清和 CSF的 MBP均显著高于正常对照组 (P<0 .0 1) ,MS组又高于 CI组 (P<0 .0 1) ;MS组中病情活动期患者 MBP又高于缓解期。结论 血清和 CSF的 MBP检测对 MS和 CI的鉴别诊断 ,以及判断 MS病情活动与否有一定价值。 MBP检测是一项比较特异、敏感可行的监控指标。
Objective To investigate the diagnostic value of MBP on cerebral infarction (CI) and multiple sclerosis (MS). Methods The MBP of cerebrospinal fluid (CSF) in 114 CI patients, 28 MS patients, 24 normal controls and some patients with cerebrospinal fluid (CSF) were detected. Results The MBP in serum and CSF of patients with CI and MS were significantly higher than those of normal control group (P <0.01), MS group was higher than that of CI group (P <0.01) And higher than the remission. Conclusion Serum and CSF MBP detection of MS and CI in the differential diagnosis, and determine whether the activity of MS disease has some value. MBP test is a more specific, sensitive and feasible monitoring indicators.