论文部分内容阅读
过氧化物酶体增殖物激活型受体(PPARs)是核受体超家族成员,在哺乳动物中存在3种亚型,即PPARα、PPARγ和PPARδ。PPARδ组织分布最广泛,参与脂肪组织和肌肉中脂肪酸氧化和能量解耦联,抑制巨噬细胞诱导的炎症。许多研究证明,激活组织中的PPARδ可以控制体重增加,增强身体耐力,提高胰岛素敏感性,改善动脉粥样硬化,从而为治疗代谢综合征提供了多方面治疗靶点。现重点阐述近年来PPARδ的研究进展。
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily and present in mammals three subtypes, PPARα, PPARγ, and PPARδ. PPARδ is the most widely distributed tissue involved in fatty acid oxidation and energy decoupling in adipose tissue and muscle, inhibiting macrophage-induced inflammation. Many studies have demonstrated that activating PPARδ in tissues can control weight gain, enhance endurance, improve insulin sensitivity and improve atherosclerosis, thus providing multifaceted therapeutic targets for the treatment of metabolic syndrome. Now highlight the research progress of PPARδ in recent years.