论文部分内容阅读
秀丽隐杆线虫(C.elegans)是生命科学领域非常重要的模式生物,具有寿命短、世代周期短、易于培养与观察等特点,因而被广泛用于生命科学研究,特别是在药物筛选和药物作用机制研究等方面。衰老是一个复杂的过程,是多因素共同作用的结果。在C.elegans中的抗衰老信号通路主要有3种,包括胰岛素-胰岛素样生长因子1信号通路、饮食限制信号通路和线粒体呼吸链/ATP合成信号通路。本文主要综述了基于以上3种信号通路的衰老模型以及基于以上衰老模型的抗衰老药物研究进展。此外,通过转基因或化学诱变可获得一些与衰老相关神经退行性疾病的C.elegans模型,包括帕金森病的α-突触核蛋白转基因模型、阿尔茨海默病的β-淀粉样蛋白沉积模型和亨廷顿舞蹈病的多聚谷氨酰胺聚集的转基因模型,总结了基于以上C.elegans疾病模型筛选的有效药物。随着当今社会人口老龄化的日益加重,人口老龄化已对我国社会经济的稳定和发展产生了深远影响,与此同时与衰老相关的疾病也引起了人们的广泛关注,如何安全有效地延缓衰老已成为医学界和社会关注的焦点,因而衰老机制的探索以及抗衰老药物的研究已成为当今社会研究的一大热点。在衰老与抗衰老研究中人们遴选出了各种动物衰老模型,如D-半乳糖(D-galactose,D-Gal)所致的亚急性大鼠衰老模型[1]、β淀粉样蛋白(β-amyloid
C. elegans is a very important model organism in the field of life science. It has the characteristics of short life span, short generations and easy to cultivate and observe. Therefore, C. elegans is widely used in life science research, especially in drug screening and medicine Mechanism of research and so on. Aging is a complex process that is the result of multiple factors. Three main anti-aging signaling pathways in C. elegans include the insulin-insulin-like growth factor 1 signaling pathway, the dietary restriction signaling pathway, and the mitochondrial respiratory chain / ATP synthesis signaling pathway. This review summarizes the aging models based on these three signaling pathways and the progress of antiaging drugs based on the above aging models. In addition, several C. elegans models of age-related neurodegenerative diseases can be obtained by transgenic or chemical mutagenesis, including the α-synuclein transgenic model of Parkinson’s disease, β-amyloid deposition of Alzheimer’s disease Model and Polyglutamine Aggregation Models of Huntington’s Disease, validated drugs that were screened based on the C.elegans disease model above. With the increasing aging of the population in today’s society, the aging of the population has had a profound impact on the social and economic stability and development of our country. At the same time, diseases related to aging have also drawn people’s attention and how to delay the aging safely and effectively Has become the focus of the medical community and society, so the exploration of aging mechanism and the study of anti-aging drugs have become a hot topic in today’s society. In the study of aging and anti-aging, various animal models of aging, such as sub-acute rat aging model caused by D-galactose (D-Gal) [1], β-amyloid -amyloid