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目的了解影响贵阳市艾滋病患者抗病毒治疗效果的影响因素。方法选择艾滋病综合防治信息管理系统中2014年以前首次接受抗病毒治疗的成年患者建立回顾性队列,收集患者的个人基本信息、艾滋病临床信息,并随访监测生存状况。运用频数和比率描述计数资料,运用均数和标准差描述计量资料,单因素分析采用χ~2检验,多因素分析采用Cox回归。结果 1 682例研究对象的平均年龄为(42.31±12.7)岁,男性占71.9%,已婚或同居的占57.6%,经性传播感染的占70.0%。至观察时间结束时,仍在治疗、停药、失访、死亡的构成比分别为85.0%、1.4%、5.2%、1.8%,93.5%的死亡病例死于艾滋病相关疾病。在随访期间,研究对象平均时间为(32.59±20.93)个月。多因素分析结果显示:临床II期、临床Ⅲ期、近3个月患艾滋病相关疾病、初始CD_4~+T淋巴细胞计数值介于200到350之间是引起死亡的高危因素。结论疾病预防控制部门应做好艾滋病病毒感染者及病人的随访监测工作,以尽早把握治疗最佳时机,确保治疗效果。
Objective To understand the influencing factors of antiviral therapy in AIDS patients in Guiyang. Methods A retrospective cohort of adult patients who were receiving ART for the first time before 2014 was selected in the HIV / AIDS Integrated Management Information Management System. Personal basic information and AIDS clinical information of patients were collected and followed up to monitor their survival. The frequency and the ratio were used to describe the counting data. The mean and standard deviation were used to describe the measurement data. The univariate analysis was used for Chi-square test and the multivariate analysis was Cox regression. Results The mean age of 1 682 subjects was (42.31 ± 12.7) years old, 71.9% for men, 57.6% for married or living together and 70.0% for those who had sexually transmitted infections. At the end of the observation period, 85.0%, 1.4%, 5.2%, 1.8% and 93.5% of the deaths still under treatment, withdrawal, loss of follow-up and death died from AIDS-related diseases. During the follow-up period, the average study time was (32.59 ± 20.93) months. Multivariate analysis showed that AIDS-related diseases were found in stage II, stage III and nearly 3 months. The initial CD 4 + T lymphocyte counts between 200 and 350 were the risk factors of death. Conclusion Disease prevention and control departments should do a good job of follow-up monitoring of HIV-infected patients and patients to grasp the best time for treatment and ensure the treatment effect.