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目的探讨红景天注射液活血化瘀作用机理。方法观察红景天注射液对家兔血小板聚集率、大鼠体外血栓形成及血液黏度的影响。结果红景天注射液可明显降低花生四烯酸(AA,和胶原诱导的家兔血小板聚集率(P<0.05),对二磷酸腺苷(ADP)诱导的家兔血小板聚集率有降低趋势;能显著缩短大鼠血栓长度(P<0.05),减轻血栓湿重及干重(P<0.05～0.01);降低中切速30S-1及低切速5S-1下的全血黏度(P<0.05)及血浆黏度。结论红景天注射液具有活血化瘀作用。
Objective To investigate the mechanism of action of Rhodiola injection on promoting blood circulation and removing blood stasis. Methods The effects of Rhodiola injection on the platelet aggregation of rabbits, thrombosis and blood viscosity in vitro were observed. Results Rhodiola injection could significantly reduce arachidonic acid (AA and Collagen-induced platelet aggregation in rabbits) (P<0.05), and the platelet aggregation rate induced by adenosine diphosphate (ADP) in rabbits was decreased. It can significantly shorten the length of thrombus in rats (P<0.05), reduce the wet and dry weight of thrombus (P<0.05-0.01), and reduce the viscosity of whole blood in medium shear rate 30S-1 and low shear rate 5S-1 (P< 0.05) and plasma viscosity.Conclusion Rhodiola injection has the effect of promoting blood circulation and removing blood stasis.