200年前,詹姆斯·帕金森在自己一篇开创性的论文中提出了被他称为“震颤麻痹”的疾病。200年后的今天,这种疾病被我们称为帕金森病。随着研究不断推进,我们对它的了解也越来越深入。在帕金森病患者身上,除了典型的躯体特征:如身体僵直、震颤和曳行步态,我们还观察到其他现象:比如味觉的丧失、调节心脏的神经元的死亡等。比起躯体运动状态的异常,这些症状常常令患者经历更多痛苦,也往往发生得更早。目前,科学家正在研究这些非躯体症状是否能作为帕金森病 Two hundred years ago, James Parkinson put forward a disease he called “Parkinsonism” in his seminal paper. Today 200 years later, the disease is what we call Parkinson’s disease. As the research progresses, we understand it more and more deeply. In patients with Parkinson’s disease, in addition to the typical physical characteristics: such as physical stiffness, tremor and walking gait, we also observed other phenomena: such as the loss of taste, regulating the death of the heart’s neurons. These symptoms often make patients experience more pain and often occur earlier than abnormalities in physical activity. At present, scientists are studying whether these non-somatic symptoms can be used as Parkinson’s disease