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目的探讨血红蛋白电泳对早期妊娠妇女地中海贫血的筛查价值,分析本地区的发病情况,为优生优育提高出生人口素质提供数据。方法对本院2012年2—10月早孕建卡门诊6015名孕妇进行血常规检测及地中海贫血筛查,并对筛查阳性的病例进行基因诊断。结果在6015名受检者中筛查出α地中海贫血阳性者1例,β地中海贫血阳性者65例。确诊为地中海贫血者62例,其中α地中海贫血1例,β地中海贫血61例,初步发现人群中地中海贫血基因携带率1.03%。结论湖州市早孕妇女地中海贫血基因携带率相对较低。血红蛋白电泳是地中海贫血有效的筛查方法。
Objective To investigate the screening value of hemoglobin electrophoresis for thalassemia in early pregnant women and to analyze the incidence in this area and provide data for improving the quality of birth population for prenatal and postnatal care. Methods Blood samples and thalassemia screening tests were performed on 6,015 pregnant women who were diagnosed in our hospital during the first trimester of 2012 from February to October in 2012. The patients were screened for gene diagnosis. Results Among 6015 subjects, 1 was found to be positive for α-thalassemia and 65 was β-thalassemia. 62 cases of diagnosed as thalassemia, including 1 case of α-thalassemia and 61 cases of β-thalassemia. The prevalence of thalassemia gene in the population was found to be 1.03%. Conclusion The prevalence of thalassemia gene in early pregnant women in Huzhou City is relatively low. Hemoglobin electrophoresis is an effective screening method for thalassemia.