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目的:实验观察柴芪口服液的抗抑郁作用。方法:将动物随机分为空白对照组、阳性对照(氟西汀)组、柴芪口服液高、中、低剂量组,分别灌胃给予同等容积的相应药物,qd,连续给予14d,末次给药后40min,采用小鼠悬尾实验、强迫游泳实验及开场实验等方法观察柴芪口服液的抗抑郁作用。结果:在小鼠强迫游泳实验和小鼠悬尾实验中,柴芪口服液大剂量(生药6.4 g·kg~(-1))能明显缩短两种“行为绝望”模型小鼠的不动时间;在小鼠开场实验中,柴芪口服液6.4 g·kg~(-1)使小鼠水平方向活动次数显著提高,与对照组比较有显著性差异(P<0.05)。结论:柴芪口服液具有抗抑郁作用。
Objective: To observe the antidepressant effect of Chaiqin Oral Liquid. Methods: Animals were randomly divided into blank control group, positive control (fluoxetine) group, Chaiqin oral high, middle, and low dose groups. Each group was given intragastric administration of the same volume of drug, qd, continuous administration for 14 days. 40 minutes after drug administration, the antidepressant effect of Chaiqin Oral Liquid was observed by mouse suspension test, forced swimming test and opening test. RESULTS: In the forced swimming test and the tail suspension test in mice, Chaiqin Oral Liquid (6.4 g·kg -1 crude drug) significantly reduced the incidence of two kinds of “desperate” mice. In the mouse opening test, Chaixiong Oral Liquid 6.4 g·kg~(-1) significantly increased the number of horizontal movements in mice, which was significantly different from that in the control group (P<0.05). Conclusion: Chaiqin Oral Liquid has antidepressant effect.