论文部分内容阅读
PTEN/PI3K/Akt通路是细胞整合外界刺激的主要信号转导通路之一,PTEN是PI3K/Akt通路的主要负调控因子,PTEN功能的缺失在人类肿瘤中广泛存在。除了基因或染色体本身的改变影响其功能活性或表达水平外,还有许多影响PTEN功能的因素,包括与脂膜的结合、亚细胞定位、基因转录、翻译及翻译后水平的调节等。
PTEN / PI3K / Akt pathway is one of the main signal transduction pathways for cell integration outside stimuli. PTEN is the main negative regulator of PI3K / Akt pathway. The loss of PTEN function is widespread in human tumors. In addition to changes in the gene or chromosome itself affect their functional activity or expression level, there are many factors that affect PTEN function, including lipid membrane binding, subcellular localization, gene transcription, translation and post-translational level regulation.