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炎痛喜康为较常用的非甾体消炎镇痛药,对类风湿及风湿性关节炎疗效较好。我院曾收治4例患者用该药致上消化道出血,报告如下。例1:女,20岁。患类风湿性关节炎,服炎痛喜康20mg/次,2次/日,第4天觉胃痛,继而头昏乏力,解黑便,继服该药症状逐渐加重,以“上消化道出血”入院。查体;BP12.0/8.0kPa,重贫血貌,心肺(一),双手腕、指(趾)关节僵直变形。查大便潜血(OB)++++,Hb55g/L,WBC6.8×10~9/L.plt145×10~9/L。用西米替叮等治疗,5天后大便OB(一),住院1周出院。半年后又服炎痛喜康20mg/日,服至第5天又解黑便,伴头昏、乏力、心慌而再次来院。查大便OB+++,Hb50g/L;胃镜检查:12指肠球部溃疡。经对症治疗10天后大便OB(一),Hb升至75g/L。
Yikongxi Kang for the more common non-steroidal anti-inflammatory analgesic, rheumatoid and rheumatoid arthritis better effect. 4 patients admitted to our hospital had the drug induced upper gastrointestinal bleeding, the report is as follows. Example 1: Female, 20 years old. Suffering from rheumatoid arthritis, serving Yan Tong Kang 21mg / time, 2 times / day, 4 days feel stomach pain, then dizziness, relieve melena, following the symptoms of the drug gradually aggravating to “upper gastrointestinal bleeding ”Admitted to hospital. Physical examination; BP12.0 / 8.0kPa, severe anemia appearance, heart and lung (a), both wrists, finger (toe) joint stiffness deformation. Examination of fecal occult blood (OB) ++++, Hb55g / L, WBC6.8 × 10-9 / L.plt145 × 10-9 / L. With cimetidine and other treatment, 5 days after the stool OB (a), hospitalized 1 week discharged. Six months after the inflammation pain and Hi-Health 20mg / day, served until the 5th day and then black solution, with dizziness, fatigue, palpitation and again to hospital. Check the stool OB +++, Hb50g / L; gastroscopy: 12 ulcer of the ulcer. After symptomatic treatment of stool OB 10 (a), Hb rose to 75g / L.