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目的 为探讨自身免疫抗体与不育症的关系。方法 本文用ELISA法检测了693对不明原因不育夫妇血清自身抗体发生情况,其中原发不孕386对,继发不孕232对,反复自然流产夫妇75对。结果 男方AsAb、女方AsAb、AEM、AOV、AhCG阳性率均明显高于生育对照组(P<0.01)。除AhCG在流产组高于原发不孕组外,其余抗体在各不育组间分布无显著差异。结论 自身抗体的产生可能是引起不孕或流产的重要原因,应重视不育症患者自身免疫抗体检测,以除外免疫性不育。
Objective To explore the relationship between autoimmune antibodies and infertility. Methods The serum autoantibodies of 693 pairs of unexplained infertile couples were detected by ELISA. Among them, 386 were primary infertility, 232 were secondary infertility and 75 were spontaneous abortion. Results The positive rates of AsAb and AsAb, AEM, AOV and AhCG in male were significantly higher than those in reproductive control (P <0.01). Except for AhCG in the abortion group higher than the primary infertility group, there was no significant difference in the distribution of the remaining antibodies among the different infertility groups. Conclusions The production of autoantibodies may be an important cause of infertility or miscarriage. The detection of autoimmune antibodies in infertile patients should be emphasized in order to exclude immune infertility.