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目的比较枯草杆菌二联活菌颗粒和蒙脱石散不同服药方法治疗小儿轮状病毒肠炎的疗效。方法选择2011年10月—2013年10月在广西壮族自治区南溪山医院治疗的98例小儿轮状病毒肠炎患儿作为研究对象,按照随机数表法将其分为观察组和对照组,每组49例。对照组患儿采用常规治疗方法,枯草杆菌二联活菌颗粒和蒙脱石散两种药物的服用时间随意设定,服用的剂量也采用常规剂量;观察组患儿先服用枯草杆菌二联活菌颗粒,1h后再服用蒙脱石散,2h后再进食,并且两种药物服用的剂量均为常规剂量的2倍。两组患儿经过相同时间的治疗后对其症状恢复时间和治疗效果进行观察和比较。结果观察组患儿体温恢复正常时间、止吐时间、大便次数和大便性状恢复正常时间均短于对照组,差异有统计学意义(P<0.05)。观察组患儿总有效率为95.9%,对照组为63.3%,差异有统计学意义(χ2=12.417,P<0.05)。结论枯草杆菌二联活菌颗粒和蒙脱石散应用于小儿轮状病毒肠炎中,控制好两种药物的服用顺序和服用时间,并采用加倍的剂量,能有效缩短患儿临床症状缓解时间,提高治疗效果。
Objective To compare the efficacy of Bacillus subtilis bivalent viable granules and montmorillonite powder in the treatment of pediatric rotavirus enteritis. Methods A total of 98 children with rotavirus enteritis treated in Nanxi Mountain Hospital of Guangxi Zhuang Autonomous Region from October 2011 to October 2013 were selected as study subjects and divided into observation group and control group according to random number table method Group of 49 cases. The control group of children with conventional treatment methods, Bacillus subtilis bivalent particles and montmorillonite loose two kinds of medication taking the time to set free, taking the dose is also used conventional dose; observation group of children taking sub-Bacillus subtilis live Bacteria particles, montmorillonite powder after 1h, 2h before eating, and the doses of the two drugs were 2 times the conventional dose. Two groups of children after the same time of treatment of symptoms recovery time and treatment were observed and compared. Results In the observation group, the body temperature returned to normal, the antiemetic time, stool frequency and stool recovery time were shorter than the control group, the difference was statistically significant (P <0.05). The total effective rate in observation group was 95.9% and in control group was 63.3%, the difference was statistically significant (χ2 = 12.417, P <0.05). Conclusion Bacillus subtilis bivalent granules and montmorillonite powder used in children with rotavirus enteritis, to control the taking of the two drugs and taking time and taking double doses, can effectively reduce the clinical symptoms of children with remission time, Improve the treatment effect.