手足口病(Hand-foot-mouth disease,HFMD)是由多种肠道病毒感染所致的常见传染病,其常见的病原有柯萨奇A组16型(CoxA16)和肠道病毒71型(EV71)[1-3],临床上以发热,手、足、口腔等部位出现皮疹、疱疹为特征,多发于5岁以下儿童,婴幼儿尤多。少数患儿可出现心肌炎、脑膜炎、肺水肿和急性迟缓性麻痹等并发症而导致重症病例,重症病例病情发展快,病死率高[4]。近年来安徽省手 Hand-foot-mouth disease (HFMD) is a common infectious disease caused by a variety of enterovirus infections. Common pathogens include Coxsackie A, type 16 (CoxA16) and enterovirus 71 EV71) [1-3], clinical fever, hand, foot, mouth and other parts of the rash, herpes is characterized by multiple births in children under 5 years of age, especially infants and young children. A small number of children may be myocarditis, meningitis, pulmonary edema and complications such as acute delayed paralysis and lead to severe cases, severe cases of rapid progression, high mortality [4]. Anhui Province in recent years hand