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目的:探讨桃核承气汤对四氯化碳诱导的大鼠肝损伤的保护作用。方法:30只大鼠分为正常对照组,模型组,大、小剂量桃核承气汤组和水飞蓟素组。桃核承气汤组灌胃桃核承气汤(0 .3 g/kg或0 .5 g/kg) ,水飞蓟素组灌胃水飞蓟素25 mg/kg。灌胃后1 h腹腔注射四氯化碳1 .5 mL/kg。注射24 h后将大鼠处死,检测肝组织病理学改变,血液中天门冬氨酸氨基转移酶(aspartateamino transferase ,AST)、丙氨酸氨基转移酶(alanine aminotransferase ,ALT)活性及脂质过氧化程度。结果:桃核承气汤不仅明显降低血液中AST及ALT活性,抑制四氯化碳引起的肝脏脂质过氧化,并且增加肝脏中谷胱甘肽含量;组织病理分析发现桃核承气汤可抑制脂质堆积,肝细胞坏死及淋巴细胞浸润。结论:桃核承气汤具有类抗氧化物之作用,对肝损伤有保护作用,甚至功能优于水飞蓟素。
Objective: To investigate the protective effect of Taohe Chengqi Decoction on carbon tetrachloride-induced liver injury in rats. Methods: Thirty rats were divided into normal control group, model group, large and small doses of Taohe Chengqi Decoction group and silymarin group. Taohe Chengqi Decoction group was administered with Taohua Chengqi Decoction (0.3 g/kg or 0.5 g/kg), and silymarin group was given silymarin 25 mg/kg by gavage. One hour after intragastric administration, carbon tetrachloride (1.5 mL/kg) was intraperitoneally injected. After 24 h injection, the rats were sacrificed and histopathological changes were detected. Aspartate aminotransferase (AST), alanine aminotransferase (ALT) activity and lipid peroxidation in blood were detected. degree. RESULTS: Taohe Chengqi Decoction not only reduced the AST and ALT activity in blood, but also inhibited the hepatic lipid peroxidation induced by carbon tetrachloride, and increased the content of glutathione in liver. Histopathological analysis found that Taohe Chengqi Decoction can inhibit Lipid accumulation, hepatocyte necrosis and lymphocyte infiltration. Conclusion: Taohe Chengqi Decoction has anti-oxidant effect, has protective effect on liver damage, and even has better function than silymarin.