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目的:研究住院肺结核患者医院内下呼吸道感染的临床特点、病原菌分布、耐药及临床疗效情况。方法:回顾性调查近5年来确诊肺结核,于住院期间发生结核杆菌外的下呼吸道感染179例。其中97例痰培养发现病原菌107株。其中,革兰氏阴性细菌64株,革兰氏阳性细菌27株,真菌16株。结论:由于肺结核患者免疫力低下,长期应用抗结核药物及抗生素治疗,加之肺脏结构破坏,呼吸道免疫力、防御力下降,致使多重耐药细菌、条件致病菌、真菌感染居多。临床治疗预后差。
Objective: To study the clinical characteristics, pathogen distribution, drug resistance and clinical efficacy of lower respiratory tract infection in hospitalized patients with pulmonary tuberculosis. Methods: A retrospective survey of pulmonary tuberculosis confirmed in the past 5 years, during hospitalization occurred in 179 cases of lower respiratory tract infection of Mycobacterium tuberculosis. Among them, 107 strains of pathogens were found in 97 cases of sputum culture. Among them, there were 64 Gram-negative bacteria, 27 Gram-positive bacteria and 16 fungi. Conclusion: Due to the low immunity of patients with pulmonary tuberculosis, long-term use of anti-TB drugs and antibiotics, combined with structural damage to the lungs, respiratory immunity, decreased defense, resulting in multi-drug resistant bacteria, opportunistic pathogens, mostly fungal infections. Poor prognosis of clinical treatment.