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目的探讨妊娠合并亚临床甲状腺功能减退症(subclinical hypothyroidism,SCH)的相关危险因素。方法选取2013年11月至2015年12月在成都市妇女儿童中心医院妇产科住院分娩的妊娠合并SCH患者519例为研究组,同期540例非SCH孕产妇为对照组,采用面对面询问和问卷调查方式收集两组的一般资料、本次怀孕前及孕期情况、既往妊娠史等,分析影响妊娠合并SCH的危险因素。结果相关单因素分析结果显示:年龄、孕产史、家庭人均月收入、文化程度、自然流产史、剖宫产、孕前体质量指数(body mass index,BMI)为影响妊娠合并SCH的单因素(P<0.05);Logistic回归分析结果显示:年龄≥30岁、初产者、孕前BMI<18.5 kg/m~2为影响妊娠合并SCH的危险因素(P<0.05)。结论妊娠合并SCH的发生与孕妇年龄、孕产史、孕前BMI相关。
Objective To explore the related risk factors of subclinical hypothyroidism (SCH) in pregnancy. Methods From November 2013 to December 2015, 519 pregnant women with SCH were hospitalized in Department of Obstetrics and Gynecology, Chengdu Women and Children’s Hospital, and 540 non-SCH pregnant women as the control group were enrolled in this study. Face-to-face interviews and questionnaires Survey collected two groups of general information, the situation before and during pregnancy, previous pregnancy history, analysis of the risk factors affecting pregnancy combined SCH. Results The univariate analysis showed that age, pregnancy history, per capita monthly household income, educational level, history of spontaneous abortion, cesarean section and body mass index (BMI) P <0.05). Logistic regression analysis showed that the risk factors of pregnancy complicated with SCH (P <0.05) were significantly higher in primiparous women with pre-pregnancy BMI <18.5 kg / m ~ 2. Conclusions The occurrence of pregnancy complicated with SCH is related to the age of pregnant women, the history of pregnancy and the pre-pregnancy BMI.