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为观察黄芪对缺氧性大鼠腺泡内肺动脉构形重组和肺动脉高压是否具有阻抑效应，以期为该药在肺动脉高压的防治方面提供实验依据。在常压低氧条件下，选用６０只大鼠，分低氧组、低氧加黄芪组和正常组，在实验第１５天、３０天分别测量右心室收缩压，计算右心室肥大指数、光镜与电镜观察肺血管病变及进行显微形态计量学检测，动态观察了黄芪对低氧大鼠腺泡内肺动脉构形重组及肺动脉高压的影响。结果显示黄芪不仅能拮抗缺氧性腺泡内肺动脉收缩，减轻低氧对肺动脉壁细胞的损伤，还能阻抑腺泡内肺动脉中膜肌化增强和外膜纤维母细胞增生。说明黄芪有明显阻抑低氧性腺泡内肺动脉构形重组和预防缺氧性肺动脉压升高的作用。
In order to observe whether astragalus suppresses the pulmonary constriction remodeling and pulmonary hypertension in hypoxic rat alveoli, in order to provide experimental evidence for its prevention and treatment in pulmonary hypertension. Sixty rats were randomly divided into hypoxia group, hypoxia plus Astragalus group and normal group under normal pressure and hypoxia conditions. Right ventricular systolic pressure was measured on the 15th and 30th day respectively, and the right ventricular hypertrophy index, light The pathological changes of pulmonary vessels were observed under microscope and electron microscope. The morphological changes of pulmonary arteries and hypoxia were observed dynamically. The results showed that astragalus can not only antagonize hypoxia acinar pulmonary artery contraction, reduce hypoxic pulmonary artery wall injury, but also inhibit the acinar pulmonary arterial enhancement and fibroblast proliferation. Astragalus significantly inhibited hypoxia acinar pulmonary conformational restructuring and prevention of hypoxic pulmonary hypertension.