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对 91例Ⅱ型糖尿病患者及 2 8例正常人的血清 ,用ELLSA法测定谷氨酸脱羧酶抗体(GAD Ab)及胰岛细胞抗体 (ICA)。结果 :Ⅱ型糖尿病人中抗体阳性率为 30 76% ,GAD Ab阳性为17 50 % ,ICA阳性为 15 38% ,双抗体阳性为 2 19% ,对照组GAD Ab和ICA均为阴性 ;抗体阳性各组体重指数 (BMI)较阴性组明显降低 ,且有显著性差异 ;小于 4 0岁患者抗体阳性率最高 ( 60 % ) ;血清C肽水平从低至高依次为双抗体阳性组、GAD Ab阳性组、ICA阳性组、抗体阴性组。提示GAD Ab、ICA联合检测可提高诊断成人迟发性自身免疫性糖尿病 (LADA)敏感性 ;Ⅱ型糖尿病中小于 4 0岁起病及低BMI可作为诊断LADA的一个重要线索 ;β细胞受损程度可能与自身抗体的种数及种类有关
Serum samples from 91 patients with type 2 diabetes and 28 normal controls were assayed for glutamic acid decarboxylase antibody (GAD Ab) and islet cell antibody (ICA) by ELLSA. Results: The positive rate of antibody in type Ⅱ diabetes was 30 76%, the positive rate of GAD Ab was 17 50%, the positive rate of ICA was 15 38%, the positive rate of diabodies was 2 19%, while the level of GAD Ab and ICA were negative in type Ⅱ diabetes. The body mass index (BMI) in each group was significantly lower than that in the negative group, and there was a significant difference. The antibody positive rate was the highest in patients younger than 40 years (60%). The serum C-peptide levels from low to high were diabodies positive, Group, ICA positive group, antibody negative group. These results suggest that combined detection of GAD Ab and ICA can improve the sensitivity of diagnosing late-onset autoimmune diabetes (ADL) in adults. The incidence of type 2 diabetes with onset less than 40 years old and low BMI may be an important clue to diagnose LADA. The degree may be related to the type and number of autoantibodies