TO THE EDITOR Taji et al. have reported in their study on 13 patients with gastric mucosa-associated lymphoid tissue (MALT) lymphomas an aggressive tumor course in trisomy 3 positive cases. The authors analyzed only stage I patients with classical low-grade marginal zone lymphoma of the MALT type and detected the trisomy 3 using an alpha-satellite DNA probe directed to the centromere. Their data support the observation that trisomy 3 is the most frequent cytogenetic aberration in MALT lymphomas. In our previous published series of 29 surgically resected gastrointestinal (GI) t(11;18) negative MALT TO THE EDITOR Taji et al. Have reported in their study on 13 patients with gastric mucosa-associated lymphoid tissue (MALT) lymphomas an aggressive tumor course in trisomy 3 positive cases. The authors solved only stage I patients with classical low-grade marginal zone lymphoma of the MALT type and detected the trisomy 3 using an alpha-satellite DNA probe directed to the centromere. Their data support the observation that trisomy 3 is the most frequent cytogenetic aberration in MALT lymphomas. In our previous published series of 29 surgically resected gastrointestinal (GI) t (11; 18) negative MALT