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目的探讨拉坦前列腺素(适利达)降低高眼压的临床疗效及安全性。方法将我院收治的高眼压及开角型青光眼患者46例(92眼)随机分为观察组和对照组,每组23例,观察组患者给予拉坦前列腺素1次/d;对照组患者给予噻吗心安2次/d,12周为一个疗程,观察两组患者治疗前后个时间段眼压波动情况。结果①治疗后两组患者眼压波动值明显降低(P<0.05)。②观察组患者夜间眼压及眼压波动值显著低于对照组(P<0.01);两组患者白天眼压差异无统计学意义(P>0.05)。③对照组患者治疗后心率降低,与治疗前比较差异有统计学意义(P<0.05),观察组心率与治疗前比较差异无统计学意义(P>0.05)。结论拉坦前列腺素具有良好的降眼压作用,且使用剂量小,不良反应小。
Objective To investigate the clinical efficacy and safety of latanoprost (Triptorelin) in reducing intraocular hypertension. Methods 46 patients (92 eyes) with hypertensive intraocular pressure (IOP) and open-angle glaucoma admitted to our hospital were randomly divided into observation group and control group, with 23 cases in each group. The observation group was treated with latanoprost once per day. The control group Patients given timolol 2 times / d, 12 weeks for a course of treatment were observed before and after treatment in two groups of intraocular pressure fluctuations. Results ① After treatment, the fluctuation of intraocular pressure was significantly lower in both groups (P <0.05). ② The intraocular pressure and intraocular pressure fluctuation in the observation group were significantly lower than those in the control group (P <0.01). There was no significant difference in intraocular pressure between the two groups in the daytime (P> 0.05). ③ The heart rate of the control group decreased after treatment, and there was significant difference between before and after treatment (P <0.05). There was no significant difference between the observation group and before treatment (P> 0.05). Conclusions Latanoprost has a good ocular hypotensive effect, and the use of small doses, adverse reactions.