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本文用微量细胞毒试验检测117例乙型肝炎患者的HLA表现型,结果表明不同临床型乙型肝炎其HLA-A、B分布不尽相同。慢活肝患者不仅与HLA-A_9抗原相关联,且与A_3、A_(28)抗原亦有关联,HLA-B_(40)抗原频率则低于对照组;急性肝炎HLA-A_(28)和B_(13)高于对照组,A_(11)抗原频率低于对照组,经统计学处理均有显著差异。慢迁肝B_(13)和B_(40)抗原频率低于对照组;HBsAg携带者B_(13)、B_(15)和B_(17)及肝炎后肝硬化者HLA-Bw_(35)都高于对照组,但均无统计学意义。由此提示研究HLA的不同表现型或将有助于进一步阐明乙型肝炎的遗传免疫发病机理和开展免疫防治。
In this paper, the detection of HLA phenotype in 117 patients with hepatitis B using the cytotoxicity assay showed that the distribution of HLA-A and B in different clinical hepatitis B were different. The patients with chronic liver disease were not only associated with HLA-A_9 antigen but also with A_3 and A_ (28) antigens. The frequency of HLA-B_ (40) antigen was lower than that of the control group. (13) higher than the control group, A (11) antigen frequency lower than the control group, statistically significant differences. The frequency of B_ (13) and B_ (40) antigens in slow-moving liver was lower than that in the control group. HLA-Bw_ (35) in HBsAg carriers B_ (13), B_ (15) and B_ (17) In the control group, but no statistically significant. This suggests that the study of different phenotypes of HLA or will help further clarify the pathogenesis of hepatitis B genetic immunization and immunoprophylaxis.