Barrett食管(Barrett′s esophagus,BE)是指鳞柱状上皮结合部移行至胃食管连接部近端且伴有肠腺化生的疾病[1]。BE是一种癌前病变,与食管腺癌关系密切。近年来BE的发病率呈逐年上升趋势,已成为西方国家食管腺癌发病率大幅度增高的直接原因。本文就BE的发病机制、筛查与监测、异 Barrett’s esophagus (BE) refers to the migration of squamous epithelial junction to the proximal end of the gastroesophageal junction accompanied by intestinal metaplasia [1]. BE is a precancerous lesion, and esophageal adenocarcinoma are closely related. In recent years, the incidence of BE showed an upward trend year by year, which has become the direct cause of the significant increase in the incidence of esophageal adenocarcinoma in western countries. This article on the pathogenesis of BE, screening and monitoring, different