贲门癌组织P53、P21和CD_44V6蛋白的表达及其意义

来源 :现代肿瘤医学 | 被引量 : 0次 | 上传用户:aihaiyuguijing
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目的探讨P53、P21和CD44v6蛋白的表达情况与贲门癌生物学行为的关系.方法采用免疫组化法对41例贲门癌组织进行P53、P21和CD44V6蛋白的测定.结果贲门癌组织中P53、P21和CD44V6蛋白的阳性率分别为75.6%、53.6%和41.4%,其表达与患者性别、年龄、临床分期和病理类型无明显关系.CD44V6蛋白阳性表达与肿瘤浸润深度有关(P<0.05);P53蛋白表达与P21蛋白表达呈正相关,但无统计学意义.P53、P21和CD44v6蛋白阳性者预后比其阴性者差.结论P53、P21和CD44v
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